Sirtuin 1 Activation: Caloric Restriction, NMN and the Sinclair Hypothesis

The Longevity Switch: A family of seven proteins, present in nearly every cell of your body, controls whether you age the way your grandparents did or something more like the way modern rodents on caloric restriction do. The proteins are called sirtuins, and the most contested research in modern longevity science centres on whether their … Read more

Why Cold Exposure Up-Regulates Brown Fat Gene Expression

The Furnace Most Adults Have Switched Off: Hidden between your shoulder blades and around your collarbones is a metabolically active tissue that, when functioning normally, can burn substantial calories without movement, raise insulin sensitivity, and shift gene expression in directions associated with metabolic health. The tissue is called brown adipose tissue (BAT), and the modern … Read more

Histone Acetylation and Memory: The Chromatin Layer That Stores Learning

The Memory Switch You Did Not Know You Had: A specific chemical modification of the proteins that package your DNA controls whether a memory becomes durable or evaporates within hours. The modification is called histone acetylation, and its dynamic regulation across the hours and days after a learning event determines, more than nearly any other … Read more